Science is filled with examples of major discoveries that were initially underappreciated. Alexander Fleming abandoned his work on penicillin. Max Born won the Nobel Prize in physics for a footnote he added in proof to a paper – a footnote that explains how the quantum mechanical wavefunction is connected to probabilities. That’s perhaps the most important idea anyone had in twentieth century physics. Assessing science is hard.
--Michael Nielsen on perhaps the most influential footnote of all time